| Title | Serum lipid profiles among patients initiating ritonavir-boosted atazanavir versus efavirenz-based regimens. | | Author(s) | Ganesan A, Benning L, Golub ET, Riddle M, Crum-Cianflone N, Tasker S, Jacobson L, Gange SJ | | Source | AIDS Res Ther 2009 Jun 22; 6(1):13. | | Abstract | ABSTRACT:
BACKGROUND: Antiretrovirals used to treat HIV-infected patients have the potential to adversely affect serum lipid profiles and increase the risk of cardiovascular disease which is an emerging concern among HIV-infected patients. Since boosted atazanavir and efavirenz are both considered preferred antiretrovirals, a head to head comparison of their effects on serum lipids is needed.
Aim: The primary objective of the study was to compare the effects of atazanavir (boosted and unboosted) and efavirenz- based regimens on serum lipid profiles.
Study Design: Prospective cohort study nested within three ongoing cohorts of HIV-infected individuals. Study Population and
Methods: Participants initiating either atazanavir or efavirenz-based regimens, with documented pre- and post-initiation lipid values. Multivariate linear regression was conducted to estimate adjusted mean differences between treatment groups for high density lipoprotein cholesterol (HDL-c), non-HDL-c, and log total cholesterol (TC) to HDL-c ratio outcomes; log-linear regression models were used to estimate differences in prevalence of low HDL-c and desirable TC.
RESULTS: The final study population was comprised of 380 efavirenz and 281 atazanavir initiators. Both atazanavir and efavirenz users had increases in serum HDL-c and decreases in TC/HDL ratio. In comparison to individuals initiating efavirenz, boosted atazanavir users on average had lower HDL-c (-4.12 mg/dl, p<0.001) and non HDL-c (-5.75 mg/dl, p<0.01), but similar declines in TC/HDL ratio.
CONCLUSION: Both efavirenz and atazanavir-based regimens (boosted and unboosted) resulted in similar beneficial declines in the TC/HDL ratio. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19545433 |
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