Pandori M, Barry PM, Wu A, Ren A, Whittington WL, Liska S, Klausner JD
Identification of Mosaic Neisseria gonorrhoeae Penicillin-Binding Protein 2 -- 2008, San Francisco, California. [JOURNAL ARTICLE]
Antimicrob Agents Chemother 2009 Jun 22.
Using a real-time PCR assay specific for a mosaic penA allele that has been associated with oral cephalosporin resistance in Asia, fifty-four available Neisseria gonorrhoeae isolates collected in San Francisco from January-October, 2008 were analyzed. Five isolates tested positive for the mosaic penA gene by real-time PCR. DNA Sequencing revealed two mosaic penA alleles (SF-A and SF-B). Isolates with SF-A and SF-B alleles possessed elevated MIC for the oral cephalosporins cefpodoxime and cefixime.
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