| Title | Cixutumumab. | | Author(s) | McKian KP, Haluska P | | Institution | Mayo Clinic College of Medicine, Division of Medical Oncology, 200 First St. SW Rochester, 55905 MN, USA +1 507 266 0029 ; +1 507 284 1803 ; haluska.paul@mayo.edu. | | Source | Expert Opin Investig Drugs 2009 Jul; 18(7):1025-33. | | Abstract | The IGF pathway plays a major role in cancer cell proliferation, survival and resistance to antineoplastic therapies in many human malignancies. As such, interference with this pathway is the target of many investigational pharmacologic agents. Cixutumumab, a monoclonal antibody to IGF-1R, utilizes this concept. In this review, we summarize preclinical, pharmacologic and early clinical data regarding this agent and discuss the impact this drug might have on the future treatment of human cancers. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19548856 |
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