| Title | Recent Developments in the Chemistry of Thebaine and its Transformation Products as Pharmacological Targets. | | Author(s) | Berényi S, Csutorás C, Sipos A | | Institution | Department of Organic Chemistry, University of Debrecen, P. O. Box 20, H-4010, Debrecen, Hungary. asipos@puma.unideb.hu. | | Source | Curr Med Chem 2009 Sep 1. | | Abstract | The most practical synthetic routes to the preparation of as important pharmaceuticals as oxycodone, naloxone, naltrexone, nalbuphine and buprenorphine have utilized the alkaloid, thebaine, as a starting material. This review intends to focus on chemical transformations of morphinans which resulted in morphinandiene derivatives with well-established and novel pharmacological potencies. These chemical transformations were mainly associated with the formation and substitution of the unique diene structure of the ring C of the morphinan backbone. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19548872 |
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