| Title | Excessive Loss of Skeletal Muscle Mass in Older Adults with Type 2 Diabetes. | | Author(s) | Park SW, Goodpaster BH, Lee JS, Kuller LH, Boudreau R, de Rekeneire N, Harris TB, Kritchevsky S, Tylavsky FA, Nevitt M, Cho YW, Newman AB, for the Health ABC Study | | Institution | Department of Internal Medicine, CHA Univetsity, Sungnam, Korea. | | Source | Diabetes Care 2009 Jun 23. | | Abstract | Objective: A loss of skeletal muscle mass is frequently observed in older adults. The aim of the study was to investigate the impact of type 2 diabetes on the changes in body composition, with particular interest in the skeletal muscle mass. Research design and methods: We examined total body composition by dual energy X-ray absorptiometry annually for six years in 2,675 older adults. We also measured mid-thigh muscle cross-sectional area (CSA) by computed tomography in Year 1 and Year 6. At baseline, 75g oral glucose challenge test was performed. Diagnosed diabetes (n, 402, 15.0%) was identified by self-report or use of hypoglycemic agents. Undiagnosed diabetes (n, 226, 8.4%) was defined by fasting plasma glucose >/= 7 mmol/l or 2-hour post-challenge plasma glucose >/= 11.1 mmol/l. Longitudinal regression models were fit to examine the effect of diabetes on the changes in body composition variables.
Results: Older adults with either diagnosed or undiagnosed type 2 diabetes showed excessive loss of appendicular lean mass and trunk fat mass compared with non-diabetic subjects. Thigh muscle CSA declined two times faster in older women with diabetes than non-diabetic counterpart. These findings remained significant after adjusting for age, sex, race, clinic site, baseline body mass index, weight change intention, and actual weight changes over time.
Conclusions: Type 2 diabetes is associated with excessive loss of skeletal muscle and trunk fat mass in the community-dwelling older adults. Older women with type 2 diabetes are at especially high risk for loss of skeletal muscle mass. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19549734 |
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