Nakaya K, Oshima T, Kudo T, Aoyagi I, Katori Y, Ota J, Hidaka H, Oda K, Kobayashi T
New treatment for invasive fungal sinusitis: Three cases of chronic invasive fungal sinusitis treated with surgery and voriconazole. [JOURNAL ARTICLE]
Auris Nasus Larynx 2009 Jun 22.
Invasive fungal sinusitis is a relatively rare disease and can be divided into acute fulminant, chronic, and granulomatous invasive fungal sinusitis. The conventional treatment is radical surgery combined with systemic amphotericin B administration, but the poor prognosis and unestablished treatment options require a better therapeutic strategy. We report three cases of chronic invasive fungal sinusitis successfully treated with a combination of surgery and voriconazole, a new antifungal agent, with good responses in all patients. Voriconazole administration could form the basis for a new standard treatment for invasive fungal sinusitis.
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