| Title | Tigecycline attenuates staphylococcal superantigen-induced T-cell proliferation and production of cytokines and chemokines. | | Author(s) | Saliba R, Paasch L, Solh AE | | Institution | The Veterans Affairs Western New York Healthcare System and the Western New York Respiratory Research Center, Department of Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, New York, USA. | | Source | Immunopharmacol Immunotoxicol 2009 Apr 21. | | Abstract | The purpose of this study is to examine the in vitro modulatory effect of tigecycline on staphylococcal superantigen-induced T-cell activation and cytokines and chemokines production by human peripheral blood mononuclear cells (PBMC). Isolated human PBMC from ten healthy volunteers were stimulated by staphylococcal enterotoxin B (SEB) and Staphylococcal toxic shock syndrome toxin-1 (TSST-1) superantigens with varying concentrations of tigecycline. Cytokines IL-1beta, IL-6, TNF-alpha, and chemokines MIP-1alpha and MIP-1beta concentrations were measured along with T cell proliferation. Results demonstrated that tigecycline alters cytokine production and reduces T-cell proliferation in vitro suggesting an immunomodulatory activity independent of its antimicrobial effect. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19555199 |
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