Preparation, characterization, and in vitro release of new transdermal methimazole as alternative to oral delivery. Drug delivery [Drug Deliv] Journal article | | Title | Preparation, characterization, and in vitro release of new transdermal methimazole as alternative to oral delivery. | | Author(s) | Morales ME, Clarés B, López-Viota M, Ruiz MA | | Institution | Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Granada, Spain. | | Source | Drug Deliv 2009 Jan; 16(1):1-10. | | Abstract | Our objective has been the development and study of the stability of transdermal methimazole formulae as alternative to oral administration. Preparation of F-127 and PLO Pluronic gel (Pluronic lecitin organogel) are described, as well as their characteristics from transmission electron microscopy. The possible structural and rheological changes to both transdermal forms were studied in terms of composition, temperature and time. The trial period was from 24 hr to 3 months after preparation. Furthermore, identical tests were carried out on formulae conserved for 1 year after production to check their integrity. Studies of release in vitro were carried out showing that the selected excipients do not pose an obstacle to the cession of methimazole, even though the PLO samples were made more slowly. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19555302 |
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