Antihyperlipidemic effect of Garlip, a polyherbal formulation in streptozotocin induced diabetic rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] Journal article | | Title | Antihyperlipidemic effect of Garlip, a polyherbal formulation in streptozotocin induced diabetic rats. | | Author(s) | Banu GS, Kumar G, Murugesan AG | | Institution | Centre for Biotechnology, Muthayammal College of Arts and Sciences, Kakkaveri, Rasipuram, Namakkal, Tamilnadu 637408, India. | | Source | Food Chem Toxicol 2009 Jun 22. | | Abstract | This study was undertaken to investigate the effect of Garlip, a poly herbal drug composed of aqueous extract of six medicinal plants on blood glucose, plasma insulin, tissue lipid profile, and lipidperoxidation in streptozotocin induced diabetic rats. Aqueous extract of Garlip a, poly herbal drug was administered orally (200 mg/kg body weight) for 30 days. The different doses of Garlip on blood glucose and plasma insulin in diabetic rats were studied and the levels of lipid peroxides [TBARS, and Hydroperoxide] and tissue lipids [cholesterol, triglyceride, phospholipides and free fatty acids] were also estimated in streptozotocin induced diabetic rats. The effects were compared with tolbutamide. Treatment with Garlip and tolbutamide resulted in a significant reduction of blood glucose and increase in plasma insulin. Garlip also resulted in a significant decrease in tissue lipids and lipid peroxide formation. The effect produced by Garlip was comparable with that of tolbutamide. The decreased lipid peroxides and tissue lipids clearly showed the antihyperlipidemic and antiperoxidative effect of Garlip apart from its antidiabetic effect. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19555732 |
|
|
| |
Advertise on this site.
| | |
|
