| Title | Theophylline attenuates hippocampal blood flow responses induced by tooth pulp stimulation in rats. | | Author(s) | Hasegawa M, Hada J, Abe T, Honda K, Shimizu A, Urade M | | Institution | Department of Dentistry and Oral Surgery, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan. | | Source | Neurosci Res 2009 Jun 23. | | Abstract | In this study, we performed tests to determine whether tooth pulp stimulation (TPS) increases hippocampal blood flow (HBF), and if so, to investigate whether the increase in HBF is mediated via the activation of adenosine receptors. We measured HBF in urethane-anesthetized rats using laser Doppler flowmetry (LDF) and examined the effect of theophylline, a nonselective adenosine receptor antagonist, on TPS-induced HBF responses. TPS increased HBF, and its response was significantly attenuated by the intraperitoneal administration of theophylline (20mg/kg). These results suggest that the HBF response induced by TPS may be, at least in part, produced through adenosine receptors. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19559058 |
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