The concurrent validity and responsiveness of the health utilities index (HUI 3) among patients with advanced HIV/AIDS. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation [Qual Life Res] Journal article | | Title | The concurrent validity and responsiveness of the health utilities index (HUI 3) among patients with advanced HIV/AIDS. | | Author(s) | Nosyk B, Sun H, Bansback N, Guh DP, Li X, Barnett P, Bayoumi A, Griffin S, Joyce V, Holodniy M, Owens DK, Anis AH | | Institution | Canadian HIV Trials Network, St. Paul's Hospital, 620-1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada, bnosyk@mail.cheos.ubc.ca. | | Source | Qual Life Res 2009 Jun 27. | | Abstract | OBJECTIVES: To assess the concurrent validity and responsiveness of the Health Utility Index 3 (HUI3) in patients with advanced HIV/AIDS, and to determine the responsiveness of this measure, the MOS-HIV and EQ-5D to HIV-related clinical events.
METHODS: Data from the OPTIMA (OPTions In Management with Antiretrovirals) trial was analyzed. Two aspects of the validity of the HUI3 were considered: concurrent validity was evaluated using Spearman correlations with MOS-HIV component and summary scores. Responsiveness to AIDS-defining events (ADE) and all adverse events (our external change criterion) was assessed using area under the receiver operating characteristic (AUROC) curves.
RESULTS: The study enrolled 368 patients (mean follow-up: 3.66 years); 82% had at least one severe adverse event and 27% had at least one ADE. The HUI3 scale and items showed good concurrent validity, with 85% of the expected relationships with the MOS-HIV subscales verified. The HUI3 was responsive to both adverse events (AUROC [95%CI]: 0.68 [0.57, 0.80]) and ADEs (0.62 [0.51, 0.74]). The EQ-5D was responsive to ADEs (0.66 [0.56, 0.76]), but not responsive to adverse events (0.56 [0.46, 0.68]).
CONCLUSION: The HUI3 is a valid and responsive measure of the change in HRQoL associated with clinical events in an advanced HIV/AIDS population. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19562514 |
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