| Title | The Pholcodine Story. | | Author(s) | Florvaag E, Johansson SG | | Institution | Laboratory of Clinical Biochemistry, Haukeland University Hospital, N-5021 Bergen, Norway; Section for Clinical Allergology, Department of Occupational Medicine, Haukeland University Hospital, N-5021 Bergen, Norway; Institute of Internal Medicine, University of Bergen, N-5021 Bergen, Norway. | | Source | Immunol Allergy Clin North Am 2009 Aug; 29(3):419-427. | | Abstract | Anaphylactic reactions to neuromuscular blocking agents during general anesthesia constitute a major cause of concern and a great source of debate among anesthesiologists. The authors' recent investigations, taking the striking differences of incidence between Norway and Sweden as the point of departure, have provided valuable insights into the pathogenetic mechanisms and the highly uneven geographical distribution of these rare, but dramatic and notoriously unpredictable, events. Eventually, a cough syrup containing pholcodine emerged as the most likely suspect. This new knowledge led to the withdrawal of the drug from the Norwegian market and to the examination of the role of pholcodine-containing drugs in other countries. The present article is a brief summary of the research behind this development. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19563989 |
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