Wu M, von Eiff C, Al Laham N, Tsuji BT
Vancomycin and Daptomycin Pharmacodynamics Differ Against a Site-Directed Staphylococcus epidermidis Mutant Displaying the Small Colony Variant Phenotype. [JOURNAL ARTICLE]
Antimicrob Agents Chemother 2009 Jun 29.
Catheter-related bloodstream infections due to slow-growing Staphylococcus epidermidis small colony variants (SCVs) are extremely difficult-to-treat. Daptomycin and vancomycin pharmacodynamics were evaluated against a site directed hemB mutant of S. epidermidis displaying the SCV phenotype and compared to the parental strain. Maximal effect decreased by 7.7-fold for vancomycin and 1.5-fold for daptomycin against the SCV mutant which was well characterized by a hill type mathematical model (R(2) >0.97).
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