| Title | Vancomycin and Daptomycin Pharmacodynamics Differ Against a Site-Directed Staphylococcus epidermidis Mutant Displaying the Small Colony Variant Phenotype. | | Author(s) | Wu M, von Eiff C, Al Laham N, Tsuji BT | | Institution | Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences Buffalo and The New York State Center of Excellence in Bioinformatics & Life Sciences, University at Buffalo, New York 14260; Institute of Medical Microbiology, University of Münster, Münster, Germany; Roswell Park Cancer Institute Department of Medicine, Buffalo, NY, 14260. | | Source | Antimicrob Agents Chemother 2009 Jun 29. | | Abstract | Catheter-related bloodstream infections due to slow-growing Staphylococcus epidermidis small colony variants (SCVs) are extremely difficult-to-treat. Daptomycin and vancomycin pharmacodynamics were evaluated against a site directed hemB mutant of S. epidermidis displaying the SCV phenotype and compared to the parental strain. Maximal effect decreased by 7.7-fold for vancomycin and 1.5-fold for daptomycin against the SCV mutant which was well characterized by a hill type mathematical model (R(2) >0.97). | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19564372 |
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