| Title | Imaging of glioma tumor with endogenous fluorescence tomography. | | Author(s) | Kepshire DS, Gibbs-Strauss SL, O'Hara JA, Hutchins M, Mincu N, Leblond F, Khayat M, Dehghani H, Srinivasan S, Pogue BW | | Institution | Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755ART Advanced Research Technologies Inc, Saint-Laurent, Quebec, Canada H4S 2A4University of Exeter, School of Physics, Stocker Road, Exeter, EX4 4QL, United KingdomDartmouth Medical School, Department of Diagnostic Radiology, Hanover, New Hampshire 03755. | | Source | J Biomed Opt 2009 May/June; 14(3):030501. | | Abstract | Tomographic imaging of a glioma tumor with endogenous fluorescence is demonstrated using a noncontact single-photon counting fan-beam acquisition system interfaced with microCT imaging. The fluorescence from protoporphyrin IX (PpIX) was found to be detectable, and allowed imaging of the tumor from within the cranium, even though the tumor presence was not visible in the microCT image. The combination of single-photon counting detection and normalized fluorescence to transmission detection at each channel allowed robust imaging of the signal. This demonstrated use of endogenous fluorescence stimulation from aminolevulinic acid (ALA) and provides the first in vivo demonstration of deep tissue tomographic imaging with protoporphyrin IX. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19566285 |
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