| Title | Intraluminal fluorescence spectroscopy catheter with ultrasound guidance. | | Author(s) | Stephens DN, Park J, Sun Y, Papaioannou T, Marcu L | | Institution | University of California, Davis, Department of Biomedical Engineering, 451 Health Sciences Drive, Davis, California 95616Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, California 90048. | | Source | J Biomed Opt 2009 May-Jun; 14(3):030505. | | Abstract | We demonstrate the feasibility of a time-resolved fluorescence spectroscopy (TRFS) technique for intraluminal investigation of arterial vessel composition under intravascular ultrasound (IVUS) guidance. A prototype 1.8-mm (5.4 Fr) catheter combining a side-viewing optical fiber (SVOF) and an IVUS catheter was constructed and tested with in vitro vessel phantoms. The prototype catheter can locate a fluorophore in the phantom vessel wall, steer the SVOF in place, perform blood flushing under flow conditions, and acquire high-quality TRFS data using 337-nm wavelength excitation. The catheter steering capability used for the coregistration of the IVUS image plane and the SVOF beam produce a guiding precision to an arterial phantom wall site location of 0.53+/-0.16 mm. This new intravascular multimodal catheter enables the potential for in vivo arterial plaque composition identification using TRFS. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19566287 |
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