Omental adipose tissue 11{beta}-HSD1 oxoreductase activity, body fat distribution and metabolic alterations in women. The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] Journal article | | Title | Omental adipose tissue 11{beta}-HSD1 oxoreductase activity, body fat distribution and metabolic alterations in women. | | Author(s) | Veilleux A, Rhéaume C, Daris M, Luu-The V, Tchernof A | | Institution | Molecular Endocrinology and Oncology Research Center; Department of Food Science and Nutrition, Laval University; and Gynecology Unit, Laval University Medical Research Center. | | Source | J Clin Endocrinol Metab 2009 Jun 30. | | Abstract | CONTEXT: Modulation of adipose tissue exposure to active glucocorticoids by type 1 11beta-hydroxysteroid dehydrogenase (11beta-HSD1) is involved in abdominal obesity of rodent models, but only a few studies have related 11beta-HSD1 oxoreductase activity to fat distribution in humans.
OBJECTIVE: To examine the link between 11beta-HSD1 oxoreductase activity, fat distribution patterns and the metabolic profile in women.
METHODS: Omental (OM) and subcutaneous (SC) adipose tissue samples were obtained from 36 lean to obese women (age: 47.2+/-5.3 years; BMI: 29.1+/-5.2 kg/m(2)) undergoing gynaecological surgery. Measures of body composition, fat distribution, blood lipids and insulin sensitivity were obtained. 11beta-HSD1 oxoreductase activity was measured over a 24h period by the reduction of [(14)C]cortisone in adipose tissue homogenates.
RESULTS: 11beta-HSD1 oxoreductase activity was higher in OM compared to SC adipose tissue (9.6+/-4.9 vs. 7.9+/-4.2 pmol/mg/h, p<0.01). OM 11beta-HSD1 oxoreductase activity was positively associated with OM adipocyte size (r=0.67, p<0.0001) and visceral adipose tissue area (r=0.57, p<0.0003). A positive correlation was also observed between the OM/SC 11beta-HSD1 oxoreductase activity ratio and the OM/SC adipocyte size ratio (r=0.37, p<0.05) as well as the visceral/subcutaneous adipose tissue area ratio (r=0.36, p<0.05). Women in the highest tertile of OM 11beta-HSD1 oxoreductase activity had larger OM adipocytes, increased OM lipolysis, increased lipoprotein lipase activity, decreased HDL cholesterol, decreased adiponectin levels and an increased HOMA-IR index compared to women in the lower tertile (p<0.05).
CONCLUSIONS: These results suggest that a relatively higher 11beta-HSD1 activity in OM vs. SC adipose tissue is associated with preferential visceral fat accumulation and concomitant metabolic alterations. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19567539 |
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