Andersohn F, Konzen C, Bronder E, Klimpel A, Garbe E
Citalopram-induced bleeding due to severe thrombocytopenia. [Journal Article, Research Support, Non-U.S. Gov't]
Psychosomatics 2009 May-Jun; 50(3):297-8.
BACKGROUND: In case reports and observational studies, serotonin reuptake-inhibitors (SSRIs) have been linked to an increased risk of bleeding, possibly due to platelet dysfunction as a consequence of serotonin-uptake blockade into platelets.
OBJECTIVE: The authors propose that bleeding as a result of SSRI use may also be caused by other mechanisms.
METHOD: Here, the authors report on a 32-year-old woman with hemorrhages resulting from severe drug-induced immune thrombocytopenia after 4 weeks of citalopram therapy.
RESULTS: After withdrawal of citalopram and treatment with platelet concentrates and prednisolone, the patient recovered completely.
CONCLUSION: As this case report shows, drug-induced immune thrombocytopenia may present another possible mechanism for bleeding in SSRI-treated patients.
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