| Title | Intravenous thrombolysis for acute ischemic stroke: The Malabar experience 2003 to 2008. | | Author(s) | Salam KA, Ummer K, Pradeep Kumar VG, Noone ML, Laila A, Ragini J | | Institution | Department of Neurological Sciences, Baby Memorial Hospital, Indira Gandhi Road, Calicut 673004, Kerala, India. | | Source | J Clin Neurosci 2009 Jun 29. | | Abstract | We report the 5-year experience with thrombolysis in acute ischemic stroke from a tertiary care hospital in the Malabar region of South India. All stroke patients thrombolyzed with intravenous recombinant tissue plasminogen activator (rt-PA) from May 2003 to May 2008 were studied in an open, non-randomized, prospective study. Of 2,308 ischemic stroke patients admitted, 57 patients (2.5%) were thrombolyzed with rt-PA (age range, 35-78years: 40 males, 17 females). The time from presentation at the hospital to initiation of thrombolysis ranged from 15 to 120 minutes (median 50 minutes). The dose of rt-PA used was from 0.6mg/kg to 0.9mg/kg. At 3months 29 patients (51%) were functionally independent, with a modified Rankin scale score of 2 or less. Seven patients (12%) died within 3months; one had an intracerebral hemorrhage (1.7%). The benefit of treatment was seen in all stroke subtypes. We have been able to show that intravenous thrombolysis in acute ischemic stroke is safe, effective and feasible in our part of the world. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19570685 |
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