The insulin-like growth factor-I (IGF-I) generation test as an indicator of growth hormone status. Hormones (Athens, Greece) [Hormones (Athens)] Journal article

Title	The insulin-like growth factor-I (IGF-I) generation test as an indicator of growth hormone status.
Author(s)	Spiliotis BE, Alexandrides TK, Karystianos C, Vassilakos P, Zadik Z, Nikolakopoulou NM, Nikiforidis G, Beratis NG
Institution	Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, University of Patras, School of Medicine, Rion, Patras, Greece.
Source	Hormones (Athens) 2009 Apr-Jun; 8(2):117-28.
Abstract	OBJECTIVE: The aim of the study was to evaluate the IGF-I generation test (IGF-I gen) as a possible indirect test of Growth Hormone (GH) secretory status. METHODS: Sixty-five GH deficient (GHD 1 and 2) and 86 control children were studied. Children in the GHD-1 subgroup (n=33) had low GH values (<10mug/L) after clonidine and levo-dopa while those in the GHD-2 subgroup (n=32) had normal GH values afterpharmacologic provocation but low 24-hour GH secretory rates compared to 187 Normal Statured (NS) children. Of the 86 controls, who underwent IGF-I gen,50 were NS and 36 Short-Statured (SS). Serum IGF-I was measured prior to and daily during hGH administration (hGH 0.033 mg/kg/day x 4 days). RESULTS:The prepubertal and pubertal GHD-1 and GHD-2 children had low baseline IGF-I values but their peak IGF-I values during the IGF-I gen reached those of the controls. The percent increase of IGF-I during the test was greater in the GHD groups than in the controls; in the prepubertal groups: 516+/-58% in the GHD-1, 433+/-50 % in the GHD-2, 106+/-12 % in the NS, and 102+/-18 % in the SS (p=0.001); in the pubertal groups: 191+/-28 % in the GHD-1, 141+/-20 % in the GHD-2, 48+/-8 % in the NS, and 61+/-17 % in the SS (p=0.003). CONCLUSIONS: The IGF-I response during the IGF-I gen seems to reflect the GH status in children.
Language	eng
Pub Type(s)	Journal Article
PubMed ID	19570739

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