| Title | Independent elaboration of steroid hormone signaling pathways in metazoans. | | Author(s) | Markov GV, Tavares R, Dauphin-Villemant C, Demeneix BA, Baker ME, Laudet V | | Institution | Molecular Zoology Team, Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Lyon 1 and Centre National de Recherche Scientifique, Institut National de Recherche Agronomique, Ecole Normale Supérieure de Lyon, Lyon Cedex 07, France. | | Source | Proc Natl Acad Sci U S A 2009 Jul 21; 106(29):11913-8. | | Abstract | Steroid hormones regulate many physiological processes in vertebrates, nematodes, and arthropods through binding to nuclear receptors (NR), a metazoan-specific family of ligand-activated transcription factors. The main steps controlling the diversification of this family are now well-understood. In contrast, the origin and evolution of steroid ligands remain mysterious, although this is crucial for understanding the emergence of modern endocrine systems. Using a comparative genomic approach, we analyzed complete metazoan genomes to provide a comprehensive view of the evolution of major enzymatic players implicated in steroidogenesis at the whole metazoan scale. Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages, and that steroidogenic cytochrome P450 enzymes descended from those that detoxify xenobiotics. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
| | PubMed ID | 19571007 |
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