Genotypic Comparison of Invasive Neisseria meningitidis Serogroup Y isolates from the United States, South Africa and Israel, 1999-2002. Journal of clinical microbiology [J Clin Microbiol] Journal article | | Title | Genotypic Comparison of Invasive Neisseria meningitidis Serogroup Y isolates from the United States, South Africa and Israel, 1999-2002. | | Author(s) | Whitney AM, Coulson GB, von Gottberg A, Block C, Keller N, Mayer LW, Messonnier NE, Klugman KP | | Institution | Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta GA, 30333; MRC/NICD/WITS Respiratory and Meningeal Pathogens Research Unit, Medical Research Council/National Institute for Communicable Diseases/University of the Witwatersrand, Johannesburg, South Africa; Hadassah-Hebrew University Medical Center, Jerusalem; and National Center for Meningococci, The Chaim Sheba Medical Center, Tel Hashomer, Israel; and Hubert Department of Global Health and Division of Infectious Diseases, Rollins School of Public Health, Emory University, Atlanta GA, 30322. | | Source | J Clin Microbiol 2009 Jul 1. | | Abstract | The proportion of meningococcal disease in the US, South Africa, and Israel caused by Neisseria meningitidis serogroup Y (NmY) was greater than the worldwide average during the period 1999-2002. Genotypic characterization of 300 NmY isolates by MLST, 16S rRNA gene sequencing and PorA variable region typing was conducted to determine the relationships of the isolates from these 3 countries. 70 different genotypes were found. Two groups of ST-23 clonal complex isolates accounted for 88% of the US isolates, 12% of the South African isolates, and 96% of the isolates from Israel. The single common clone (ST-23/16S-19/P1.5-2,10-1) represented 57%, 5% and 35% of the NmY isolates from the US, South Africa and Israel. The predominant clone in South Africa (ST-175/16S-21/P1.5-1,2-2) and 11 other closely related clones made up 77% of the South African study isolates and were not found among the isolates from the US or Israel. ST-175 was the predicted founder of the ST-175 clonal complex, and isolates of ST-175 and related STs have been described previously in other African countries. Continued active surveillance and genetic characterization of NmY isolates causing disease in the US, South Africa, and Israel will provide valuable data for local and global epidemiology, allow monitoring for any expansion of existing clonal complexes and detection of the emergence of new virulent clones in the population. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19571028 |
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