Schwartz JB, Verotta D
Population Analyses of Atorvastatin Clearance in Patients Living in the Community and in Nursing Homes. [JOURNAL ARTICLE]
Clin Pharmacol Ther 2009 Jul 1.
The effects of demographic and clinical covariates on the apparent clearance (CL/F) of orally administered atorvastatin, with chronic dosing in a patient population that included the elderly, were studied in 143 patients (atorvastatin: 34 +/- 26 mg/day, mean +/- SD; men (n = 64), age 64.6 +/- 12.1 years, and women (n = 79), age 69.3 +/- 13 years). The time of dose administration had a strong influence on Ka (faster with morning dosing); the factors found to slow CL/F were coadministration of CYP3A inhibitors and advancing age-the latter factor was relevant only in the men, not in the women.Clinical Pharmacology & Therapeutics (2009); advance online publication 1 July 2009. doi:10.1038/clpt.2009.100.
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