Kumar S, Kumar S, Kumar V, Singh KK, Roy BK
Pharmacokinetic studies of levofloxacin after oral administration in healthy and febrile cow calves. [JOURNAL ARTICLE]
Vet Res Commun 2009 Jul 2.
The present experiment was designed to study the pharmacokinetics of levofloxacin in six healthy cross bred female cow calves (4 to 6 months age) weighing between 40 to 80 kg. Plasma from blood was separated by centrifugation at 10,000 rpm. Quantitative estimation of levofloxacin was done by UV-VIS spectrophotometer at 286 nm. The mean maximum plasma concentration (Cp(max) ) of levofloxacin in febrile calves (5.28 +/- 0.32 microg/ml) did not differ significantly as compared with healthy calves (4.50 +/- 0.22 microg/ml) after single dose (20 mg/kg) oral administration. The mean therapeutic plasma concentration ( Cp(ther) ) of levofloxacin was maintained for longer period in febrile calves (10 h) as compared to healthy calves ( 8 h). The mean maximum urine concentration (Cu(max)) in febrile (40.86 +/- 2.19 microg/ml) also did not differ significantly as compared with healthy calves (39.38 +/- 2.43 microg/ml). No significant difference in various pharmacokinetic parameters of plasma was observed in healthy calves ( beta = 0.23 +/- 0.01/h ; t1/2 beta = 3.00 +/- 0.17 h and MRT = 4.66 +/- 0.14 h ) and febrile calves ( beta = 0.23 +/- 0.01/ h; t1/2 beta = 3.05 +/- 0.16 h and MRT = 5.04 +/- 0.14 h ) . The mean value of beta, and t (1/2) beta calculated in urine also did not differ between healthy and febrile calves. However, the value of MRT(3.79 +/- 0.07 h) and Cl(B)(1.65 +/- 0.09 ml/kg/min) calculated in urine of febrile calves significantly(p < 0.05) differ to healthy calves(MRT = 3.15 +/- 0.03 h;Cl(B) = 2.09 +/- 0.13 ml/kg/min). Based on kinetic profile levofloxacin may be given orally at the dose rate of 1.49 mg/kg B.W.at 8 h intervals in febrile calves.
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