| Title | Inside Cover: Charge-Conversional Polyionic Complex Micelles-Efficient Nanocarriers for Protein Delivery into Cytoplasm (Angew. Chem. Int. Ed. 29/2009). | | Author(s) | Lee Y, Ishii T, Cabral H, Kim HJ, Seo JH, Nishiyama N, Oshima H, Osada K, Kataoka K | | Institution | Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan), Fax: (+81) 3-5841-7139. | | Source | Angew Chem Int Ed Engl 2009 Jul 1; 48(29):5220. | | Abstract | A highly efficient protein delivery into cytoplasm is described by K. Kataoka, and co-workers on page 5309 ff. The charge-density increase of a protein cargo by reversible modification, which was based on the charge-conversional moieties citaconic amide and cis-aconitic amide, helped the stability of protein/block copolymer polyionic complex (PIC) micelles. The rapid protein charge conversion in endosomes induced the dissociation of the PIC micelles and efficient endosomal escape. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19572303 |
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