| Title | Nanostructured Silica Materials As Drug-Delivery Systems for Doxorubicin: Single Molecule and Cellular Studies. | | Author(s) | Lebold T, Jung C, Michaelis J, Bräuchle C | | Institution | Department of Chemistry and Biochemistry, Center for Nanoscience (CeNS) and Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universitat Munchen, Butenandtstrasse 11, Gerhard-Ertl-Building, 81377 Munich, Germany. | | Source | Nano Lett 2009 Jul 2. | | Abstract | We apply mesoporous thin silica films with nanometer-sized pores as drug carriers and incorporate the widely used anticancer drug Doxorubicin. Through single-molecule based measurements, we gain mechanistic insights into the drug diffusion inside the mesoporous film, which governs the drug-delivery at the target-site. Drug dynamics inside the nanopores is controlled by pore size and surface modification. The release kinetics is determined and live-cell measurements prove the applicability of the system for drug-delivery. This study demonstrates that mesoporous silica nanomaterials can provide solutions for current challenges in nanomedicine. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19572735 |
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