Schachern PA, Tsuprun V, Cureoglu S, Ferrieri P, Briles DE, Paparella MM, Juhn S
Virulence of pneumococcal proteins on the inner ear. [Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't]
Arch Otolaryngol Head Neck Surg 2009 Jul; 135(7):657-61.
OBJECTIVE: To investigate the effects of the virulence characteristics of specific pneumococcal proteins on the inner ear.
MAIN OUTCOME MEASURES: A histologic comparison of inflammatory cell infiltration and pathologic changes in the round window membrane and inner ear.
RESULTS: Most of the animals inoculated with high-dose pneumolysin or wild-type bacteria showed severe pathologic changes of the inner ears. The inner ears of most animals inoculated with surface protein A or surface antigen A-deficient bacteria appeared normal.
CONCLUSIONS: Pneumococcal surface protein A and pneumococcal surface antigen A are 2 important virulence factors in inner ear damage secondary to pneumococcal otitis media. Mutation of these virulence factors results in less inner ear damage.
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