| Title | Passage-delaying microbeads for controlled delivery of loratadine. | | Author(s) | Mishra SK, Philip AK, Pathak K | | Institution | Department of Pharmaceutics, Rajiv Academy for Pharmacy, Delhi Mathura Bypass, Mathura- 281001, Uttar Pradesh, India. | | Source | PDA J Pharm Sci Technol 2008 Nov-Dec; 62(6):421-8. | | Abstract | A passage-delaying, multiple unit, controlled release system of loratadine was designed to increase residence time in the stomach involving minimum contact with the gastric mucosa. Oil-entrapped floating microbeads prepared using the emulsion gelation method were optimized by a 2(3) factorial design and a polymer ratio of 1.5:0.5 (casein:sodium alginate) by weight, and 15% w/v of oil (mineral oil/castor oil) and 1 M calcium chloride solution were selected as the optimized processing conditions for the desired buoyancy and physical stability. In vitro drug release in acid phthalate buffer, pH 3.12, demonstrated a sustained release for 8 h that best fitted the peppas model with n < 0.45. The ethylcellulose coating of the passage-delaying microbeads optimized by a 2(2) factorial design resulted in a controlled release formulation of loratadine that provided zero-order release for 8 h. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19634345 |
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