| Title | Effect of Mexiletine on Dynamic Allodynia Induced by Chronic Constriction Injury of the Sciatic Nerve in Rats. | | Author(s) | Nakazato-Imasato E, Tanimoto-Mori S, Kurebayashi Y | | Institution | Nagoya Discovery Research, Pfizer Global Research and Development, Pfizer Inc. | | Source | J Vet Med Sci 2009; 71(7):991-994. | | Abstract | Static and dynamic allodynia occurred in a rat model of neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve. Static allodynia was detected within 1 day after the CCI surgery, and persisted for 28 days. Dynamic allodynia displayed a slower course of development with a late onset, and statistically significant changes were achieved between 14 and 28 days after the surgery. Mexiletine at 10 and 30 mg/kg, s.c. produced a significant and dose-dependent inhibition of CCI-induced static and dynamic allodynia on day 14 post-surgery. Pregabalin, used as a reference drug, also significantly inhibited both static and dynamic allodynia at 30 and 60 mg/kg, p.o. These findings rationalize the clinical use of mexiletine for treatment of neuropathic pain. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19652492 |
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