| Title | Role of calcium in regulating primary sensory neuronal excitability. | | Author(s) | Gover TD, Moreira TH, Weinreich D | | Institution | Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Room 4-002, Bressler Research Building, 655 West Baltimore Street, Baltimore, MD, 21201-1559, USA. | | Source | Handb Exp Pharmacol 2009; (194):563-87. | | Abstract | The fundamental role of calcium ions (Ca(2+)) in an excitable tissue, the frog heart, was first demonstrated in a series of classical reports by Sydney Ringer in the latter part of the nineteenth century (1882a, b; 1893a, b). Even so, nearly a century elapsed before it was proven that Ca(2+) regulated the excitability of primary sensory neurons. In this chapter we review the sites and mechanisms whereby internal and external Ca(2+) can directly or indirectly alter the excitability of primary sensory neurons: excitability changes being manifested typically by variations in shape of the action potential or the pattern of its discharge. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19655118 |
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