| Title | Intestinal cholecystokinin controls glucose production through a neuronal network. | | Author(s) | Cheung GW, Kokorovic A, Lam CK, Chari M, Lam TK | | Institution | Toronto General Research Institute, University Health Network, Toronto, Canada. | | Source | Cell Metab 2009 Aug; 10(2):99-109. | | Abstract | Cholecystokinin (CCK) is a peptide hormone that is released from the gut in response to nutrients such as lipids to lower food intake. Here we report that a primary increase of CCK-8, the biologically active form of CCK, in the duodenum lowers glucose production independent of changes in circulating insulin levels. Furthermore, we show that duodenal CCK-8 requires the activation of the gut CCK-A receptor and a gut-brain-liver neuronal axis to lower glucose production. Finally, duodenal CCK-8 fails to lower glucose production in the early onset of high-fat diet-induced insulin resistance. These findings reveal a role for gut CCK that lowers glucose production through a neuronal network and suggest that intestinal CCK resistance may contribute to hyperglycemia in response to high-fat feeding. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
| | PubMed ID | 19656488 |
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