| Title | Increased peripheral blood mitochondrial DNA in type 2 diabetic patients with nephropathy. | | Author(s) | Malik AN, Shahni R, Iqbal MM | | Institution | Diabetes Research Group, Division of Reproduction and Endocrinology, King's College London, UK. | | Source | Diabetes Res Clin Pract 2009 Aug 4. | | Abstract | We report that mitochondrial DNA (MtDNA) copy numbers are increased in peripheral blood of patients with diabetic nephropathy (DN). Using qPCR for quantitation, we found a 2-4-fold significant increase (p<0.05) in the mean MtDNA values in DN patients vs. healthy controls and diabetics without nephropathy. Increased MtDNA in DN could contribute to increased oxidative stress. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19660820 |
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