Phuwapraisirisan P, Rangsan J, Siripong P, Tip-Pyang S
New antitumour fungal metabolites from Alternaria porri. [Journal Article]
Nat Prod Res 2009; 23(12):1063-71.
Chemical investigation of the onion pathogenic fungus Alternaria porri resulted in the isolation of two new phthalides named zinnimide (2) and deprenylzinnimide (8), along with a new bianthraquinone, alterporriol F (10). The structures of the new metabolites were characterised by spectroscopic analysis and chemical degradation. Of the new compounds isolated, alterporriol F was highly cytotoxic towards HeLa and KB cells, with IC(50) values of 6.5 and 7.0 microg mL(-1).
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