| Title | New antitumour fungal metabolites from Alternaria porri. | | Author(s) | Phuwapraisirisan P, Rangsan J, Siripong P, Tip-Pyang S | | Institution | Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. | | Source | Nat Prod Res 2009; 23(12):1063-71. | | Abstract | Chemical investigation of the onion pathogenic fungus Alternaria porri resulted in the isolation of two new phthalides named zinnimide (2) and deprenylzinnimide (8), along with a new bianthraquinone, alterporriol F (10). The structures of the new metabolites were characterised by spectroscopic analysis and chemical degradation. Of the new compounds isolated, alterporriol F was highly cytotoxic towards HeLa and KB cells, with IC(50) values of 6.5 and 7.0 microg mL(-1). | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19662571 |
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