Statins, fibrates and retinoic acid upregulate mitochondrial acylcarnitine carrier gene expression. Biochemical and biophysical research communications [Biochem Biophys Res Commun] Journal article | | Title | Statins, fibrates and retinoic acid upregulate mitochondrial acylcarnitine carrier gene expression. | | Author(s) | Iacobazzi V, Convertini P, Infantino V, Scarcia P, Todisco S, Palmieri F | | Institution | Department of Pharmaco-Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Bari, Italy. | | Source | Biochem Biophys Res Commun 2009 Aug 6. | | Abstract | In this study, we investigated the effects of statins, fibrates, 9-cis-retinoic acid and forskolin on the transcription of the mitochondrial carnitine/acylcarnitine carrier (CAC) gene. Statins, fibrates, retinoic acid and forskolin activate luciferase gene reporter activity driven by the -334/+3bp region of the human CAC promoter containing wild-type (but not mutated) PPRE. These four agents also increase CAC transcript and protein levels. The combinations of statins and fibrates, retinoic acid and fibrates and fibrates and forskolin act synergistically. Mevalonate abolishes the activation of CAC gene expression by statins; the inhibitor of the PKA pathway H89 suppresses the stimulation of CAC gene expression by forskolin. Because CAC is essential for fatty acid beta-oxidation, the above results on the regulation of CAC gene expression provide a novel contribution to the understanding of the hypolipidemic action of statins, fibrates and retinoic acid. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19665003 |
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