| Title | The Acute Effects of HIV Protease Inhibitors on Insulin Suppression of Glucose Production in Healthy HIV-Negative Men. | | Author(s) | Lee GA, Schwarz JM, Patzek S, Kim S, Dyachenko A, Wen M, Mulligan K, Schambelan M, Grunfeld C | | Institution | From the *Department of Medicine, University of California, San Francisco, CA; daggerMetabolism and Endocrine Sections, San Francisco Department of Veterans Affairs Medical Center, San Francisco, CA; double daggerDivision of Endocrinology, San Francisco General Hospital, San Francisco, CA; and section signCollege of Osteopathic Medicine, Touro University-California, Vallejo, CA. | | Source | J Acquir Immune Defic Syndr 2009 Aug 12. | | Abstract | BACKGROUND:: The effects of different HIV protease inhibitors (PIs) on peripheral insulin resistance have been described, but less is known about their effects on insulin suppression of endogenous glucose production (EGP).
METHODS:: We tested the acute effects of 3 PIs, indinavir, ritonavir, and amprenavir, on EGP quantified by stable isotope techniques during the hyperinsulinemic, euglycemic clamp in 3 similar placebo-controlled protocols.
RESULTS:: EGP was higher with indinavir in the hyperinsulinemic state than with placebo (4.1 +/- 1.3 vs. 2.2 +/- 0.8 mug.kg.min, P = 0.04). A trend toward higher EGP was seen with ritonavir (3.6 +/- 0.3 vs. 3.0 +/- 0.5 mug.kg.min, P = 0.08). There was no evidence that amprenavir blunted insulin suppression of EGP compared with placebo (2.9 +/- 0.04 vs. 3.2 +/- 0.7 mug.kg.min, P = 0.63).
CONCLUSIONS:: Some PIs can acutely blunt the ability of insulin to suppress EGP, but, as with insulin resistance, the effects of PIs on EGP are drug-specific, not class-specific. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19680131 |
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