Kovac S, Möddel G, Reinholz J, Alexopoulos AV, Syed T, Schuele SU, Lineweaver T, Loddenkemper T
Memory performance is related to language dominance as determined by the intracarotid amobarbital procedure. [JOURNAL ARTICLE]
Epilepsy Behav 2009 Aug 12.
OBJECTIVE: The goal of this study was to explore the relationship between language and memory lateralization in patients with epilepsy undergoing the intracarotid amobarbital procedure.
METHODS: In 386 patients, language lateralization and memory lateralization as determined by laterality index (LI) were correlated with each other.
RESULTS: Language lateralization and memory lateralization were positively correlated (r=0.34, P<0.01). Correlations differed depending on the presence and type of lesion (chi(2)=7.98, P<0.05). LIs correlated significantly higher (z=2.82, P<0.05) in patients with cortical dysplasia (n=41, r=0.61, P<0.01) compared with the group without lesions (n=90, r=0.16, P>0.05), with patients with hippocampal sclerosis falling between these two groups. Both memory (P<0.01) and language (P<0.01) LIs were higher in right- compared with left-sided lesions.
CONCLUSION: Correlation of language and memory is more pronounced in patients with structural lesions as compared with patients without lesions on MRI.
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