| Title | Amphiphilic Polymer Nanoparticles: Characterization and Assessment as New Drug Carriers. | | Author(s) | Dutta P, Shrivastava S, Dey J | | Institution | Department of Chemistry, Indian Institute of Technology, Kharagpur 721302, India. | | Source | Macromol Biosci 2009 Aug 14. | | Abstract | An amino-acid-based hydrophobically modified biocompatible copolymer, poly[(sodium N-acryloyl-L-valinate)-co-(N-octylacrylamide)] was synthesized and characterized. Techniques such as fluorescence probes, DLS, and TEM were used to investigate its aggregation behavior in aqueous solution. The copolymer was observed to form micellar aggregates having diameters in the nanometer range in aqueous solution (pH = 8) through inter-chain hydrophobic association. This behavior was found to be similar to that of poly[(sodium N-acryloyl-L-valinate)-co-(N-dodecylacrylamide)]. The compact micellar nanostructures were observed to be stable with respect to changes of pH and temperature. The encapsulation and release of griseofulvin, a hydrophobic model drug, was studied. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19685495 |
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