| Title | Antifungal activity of organotin compounds with functionalized carboxylates evaluated by the microdilution bioassay in vitro. | | Author(s) | Dyląg M, Pruchnik H, Pruchnik F, Majkowska-Skrobek G, Ułaszewski S | | Institution | Institute of Genetics and Microbiology, University of Wroclaw, Wroclaw. | | Source | Med Mycol 2009 Aug 17.:1-12. | | Abstract | We investigated the susceptibility of 96 well-characterized strains of yeast-like and filamentous fungi towards new organotin compounds: (1) [Sn(C(4)H(9))(3)(OOCC(6)H(4)SO(3)H-2)], (2) Sn(C(4)H(9))(3){OOC(CH(2))(3)P(C(6)H(5))(3)}]Br, and (3) [Sn(C(6)H(5))(3)[OOC(CH(2))(3)N(CH(3))(3)}]Cl. In the case of yeast-like fungi, the in vitro susceptibility tests were carried out according to the Clinical Laboratory Standards Institute (CLSI, formerly NCCLS) reference method M27-A2, while for filamentous fungi the investigations were conducted according to the M38-A and M38-P methods. The organotin complexes 1, 2 and 3 are active antifungal agents. Minimal inhibitory concentrations (MIC) were in the range of 0.25-4.68 microg/ml for all tested fungal strains. Considerably larger differences were found for minimal fungicidal concentrations (MFC). In the case of yeast-like fungi, the fungicidal effect was generally observed at organotin compounds concentrations of 2.34-9.37 microg/ml. The MFC values for filamentous fungi were considerably higher and were in the range of 18.74-50 microg/ml. In conclusion, organotin compounds 1, 2 and 3 showed high fungistatic and fungicidal activities against different species of pathogenic and nonpathogenic fungi. However, they were also highly cytotoxic towards two mammalian cell lines. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19688632 |
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