Gemfibrozil, stretching arms beyond lipid lowering. Immunopharmacology and immunotoxicology [Immunopharmacol Immunotoxicol] Journal article | | Title | Gemfibrozil, stretching arms beyond lipid lowering. | | Author(s) | Roy A, Pahan K | | Institution | Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA. | | Source | Immunopharmacol Immunotoxicol 2009; 31(3):339-51. | | Abstract | Gemfibrozil is long known for its ability to reduce the level of triglycerides in the blood circulation and to decrease the risk of hyperlipidemia. However, a number of recent studies reveal that apart from its lipid-lowering effects, gemfibrozil can also regulate many other signaling pathways responsible for inflammation, switching of T-helper cells, cell-to-cell contact, migration, and oxidative stress. In this review, we have made an honest attempt to analyze various biological activities of gemfibrozil and associated mechanisms that may help to consider this drug for different human disorders as primary or adjunct therapy. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 19694602 |
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