| Title | The role of an alginate suspension on pepsin and bile acids - key aggressors in the gastric refluxate. Does this have implications for the treatment of gastro-oesophageal reflux disease? |
| Author(s) | Strugala V, Avis J, Jolliffe IG, Johnstone LM, Dettmar PW |
| Institution | Technostics Ltd, Hull, UK. vicki.strugala@technostics.com |
| Source | J Pharm Pharmacol 2009 Aug; 61(8):1021-8. |
| MeSH | Alginates
Animals
Bicarbonates
Bile Acids and Salts
Colorimetry
Diffusion
Dose-Response Relationship, Drug
Drug Combinations
Esophagus
Gastroesophageal Reflux
Glucuronic Acid
Hexuronic Acids
Humans
Models, Biological
Pepsin A
Potassium Compounds
Swine
|
| Abstract | OBJECTIVES: During a reflux event the oesophagus is exposed to a heterogeneous mixture of gastric juice components. The role of non-acid components of the refluxate in causing damage to the oesophagus is now well established but no therapeutic option exists to address this.
METHODS: The role of Gaviscon Advance (GA), a raft-forming alginate suspension, in protecting the oesophagus from damage by pepsin and bile acids (aggressors) was investigated using a series of in-vitro models. KEY
FINDINGS: GA was able to dose-dependently inhibit pepsin activity over and above the neutralisation effect of the formulation. This was evident against both protein and collagen substrates using two distinct colorimetric assays. GA was able to retard the diffusion of pepsin and multiple bile acids using a Franz cell model. Using the raft-forming mode of action GA was able to remove both pepsin and multiple bile acids from a simulated reflux event. There was capacity in the GA raft to accommodate aggressors from multiple reflux events.
CONCLUSIONS: GA can specifically remove both pepsin and bile acids from the refluxate, limit their diffusion and affect enzymatic activity of pepsin. There is a role for GA to reduce the damaging potential of the refluxate and thus protect the oesophagus. |
| Language | eng |
| Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
|
| PubMed ID | 19703345 |
