Antimicrobial Resistance in Gonorrhea: The Influence of Epidemiologic and Laboratory Surveillance Data on Treatment Guidelines: Alberta, Canada 2001-2007. Sexually transmitted diseases [Sex Transm Dis] Journal article | | Title | Antimicrobial Resistance in Gonorrhea: The Influence of Epidemiologic and Laboratory Surveillance Data on Treatment Guidelines: Alberta, Canada 2001-2007. | | Author(s) | Plitt S, Boyington C, Sutherland K, Lovgren M, Tilley P, Read R, Singh AE | | Institution | From the Centre for Communicable Disease and Infection Control, Public Health Agency of Canada, Ottawa, Ontario; University of Alberta, Edmonton, Alberta; Alberta Health and Wellness, Edmonton, Alberta; Provincial Laboratory for Public Health, Edmonton, Alberta; Children's and Women's Health Centre of British Columbia, Vancouver, British Columbia; Calgary STD Clinic, Calgary, Alberta; Alberta Health Services-Edmonton STD Centre, Edmonton, Alberta. | | Source | Sex Transm Dis 2009 Aug 21. | | Abstract | OBJECTIVES:: To describe the impact of surveillance for antimicrobial resistance (AMR) in Neisseria gonorrhoeae over a 7-year period on treatment guidelines in Alberta, Canada.
METHODS:: AMR testing data from gonorrhea cases were combined with demographic and risk behavior information collected through surveillance to describe trends and sequential changes to treatment guidelines.
RESULTS:: Ciprofloxacin resistant gonorrhea (CRG) cultures rose from 1.4% in 2001 to 27.7% in 2007. Of 200 CRG cases, 90% were men, 77% white, median age 29 years (interquartile range: 23-29 years) and 60% were men who have sex with men (MSM). In 2005, only 1 of 28 cases did not fit into travel or MSM categories and treatment guidelines were changed to recommend oral cefixime as the preferred agent in MSM or those with a travel history. Continuous rise in CRG together with locally acquired cases among heterosexuals resulted in ciprofloxacin being removed as a recommended agent for gonorrhea in 2007.
CONCLUSIONS:: Our data underscores the importance of surveillance in monitoring trends in AMR in gonorrhea so that timely changes to treatment recommendations can be made in response to changing epidemiology. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19704400 |
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