Moore SM, Liang T, Graves TJ, McCall KM, Carr LG, Ehlers CL
Identification of a novel cytosolic aldehyde dehydrogenase allele, ALDH1A1*4. [Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't]
Hum Genomics 2009 Jul; 3(4):304-7.
This paper reports the identification of a novel cytosolic aldehyde dehydrogenase 1 ( ALDH1A1 ) allele. One hundred and sixty-two Indo-Trinidadian and 85 Afro-Trinidadian individuals were genotyped. A novel ALDH1A1 allele, ALDH1A1*4 , was identified in an Indo-Trinidadian alcoholic with an A inserted at position -554 relative to the translational start site, +1. It was concluded that a wider cross-section of individuals needs to be evaluated in order to determine the representative frequency of the allele, and to see if it is associated with risk of alcoholism.
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