Identification of a novel cytosolic aldehyde dehydrogenase allele, ALDH1A1*4. Human genomics [Hum Genomics] Journal article | | Title | Identification of a novel cytosolic aldehyde dehydrogenase allele, ALDH1A1*4. | | Author(s) | Moore SM, Liang T, Graves TJ, McCall KM, Carr LG, Ehlers CL | | Institution | Pharmacology Unit, Department of Paraclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad and Tobago. smmatrix2k1@yahoo.com | | Source | Hum Genomics 2009 Jul; 3(4):304-7. | | Abstract | This paper reports the identification of a novel cytosolic aldehyde dehydrogenase 1 ( ALDH1A1 ) allele. One hundred and sixty-two Indo-Trinidadian and 85 Afro-Trinidadian individuals were genotyped. A novel ALDH1A1 allele, ALDH1A1*4 , was identified in an Indo-Trinidadian alcoholic with an A inserted at position -554 relative to the translational start site, +1. It was concluded that a wider cross-section of individuals needs to be evaluated in order to determine the representative frequency of the allele, and to see if it is associated with risk of alcoholism. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
| | PubMed ID | 19706361 |
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