| Title | Etiologies of bacterial meningitis in Bangladesh: results from a hospital-based study. | | Author(s) | Gurley ES, Hossain MJ, Montgomery SP, Petersen LR, Sejvar JJ, Mayer LW, Whitney A, Dull P, Nahar N, Uddin AK, Rahman ME, Ekram AR, Luby SP, Breiman RF | | Institution | International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh. egurley@icddrb.org | | Source | Am J Trop Med Hyg 2009 Sep; 81(3):475-83. | | MeSH | Adolescent
Adult
Bangladesh
Child
Child, Preschool
Female
Hospitals
Humans
Male
Meningitis, Haemophilus
Meningitis, Meningococcal
Meningitis, Pneumococcal
Middle Aged
Young Adult
| | Abstract | We conducted a study at four hospitals from June 2003 to July 2005 to investigate the etiologies of bacterial meningitis in Bangladesh. A total of 2,609 patients met the clinical case definition, and 766 had cerebrospinal fluid tested by at least one of the following methods: latex agglutination, 16S rRNA gene sequencing, or real-time polymerase chain reaction for Neisseria meningitidis A and C, Streptococcus pneumoniae, and Haemophilus influenzae type b (Hib); culture results were noted from patient records. In total, 189 patients (24%) of those tested, representing all age groups, were diagnosed with bacterial meningitis; 136 (18%) had meningococcal, 23 (3%) had pneumococcal, and 25 (3%) had Hib infection. Twenty percent of patients with Hib meningitis (5/25) were > 15 years old. Case-fatality ratios were 10% for N. meningitidis, 22% for S. pneumoniae, and 24% for Hib. Bacterial meningitis from vaccine-preventable pathogens causes significant morbidity and mortality in Bangladesh in adults and children. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, U.S. Gov't, P.H.S.
| | PubMed ID | 19706918 |
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