Boller S, Soldi C, Marques MC, Santos EP, Cabrini DA, Pizzolatti MG, Zampronio AR, Otuki MF
Anti-inflammatory effect of crude extract and isolated compounds from Baccharis illinita DC in acute skin inflammation. [JOURNAL ARTICLE]
J Ethnopharmacol 2009 Aug 24.
ETHNOPHARMACOLOGYCAL RELEVANCE: The tea from the leaves of Baccharis illinita DC (Asteraceae family) is commonly used by the population as anti- inflammatory (including topically), protective gastric and anti-infectious. However, no studies have been done with this species to confirm its topical anti- inflammatory action.
AIM: This study evaluated he topical effects of crude extract of leaves (CE) and its active constituents in 12-O-tetradecanoilforbol acetate (TPA)-induced ear oedema.
METHODOLOGY: CE and compounds effects were tested in commonly used models of TPA-, arachidonic acid (AA)- and capsaicin-ear oedema. Polymorphonuclear (PMN) cell migration was evaluated by mieloperoxidase and analyzed histologically.
RESULTS: CE (0.1- 1mg/ear) caused a dose-related inhibition of TPA-induced ear oedema and PMN influx similarly to that produced by topical application of the steroidal antiinflammatory drug dexamethasone. The active constituents of the AcOEt fraction kaurenoic acid, a -Spinasterol, oleanolic acid and Baurenol also inhibited TPA-induced ear edema. Histological analysis of the ear of CE- treated animals confirmed the reduction of edema and of PMN infiltration. Both CE and the nosteroidal anti-inflammatory drug indomethacin inhibited the AA- induced ear oedema, but did not change capsaicin-induced oedema.
CONCLUSION: These results indicate that the CE and the active constituents have a topical anti-inflammatory effect and the possible mechanisms for the pharmacological effects are discussed.
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