Identification of methysticin as a potent and non-toxic NF-kappaB inhibitor from kava, potentially responsible for kava's chemopreventive activity. Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] Journal article | | Title | Identification of methysticin as a potent and non-toxic NF-kappaB inhibitor from kava, potentially responsible for kava's chemopreventive activity. | | Author(s) | Shaik AA, Hermanson DL, Xing C | | Institution | Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, 308 Harvard St SE, Minneapolis, MN 55455, United States. | | Source | Bioorg Med Chem Lett 2009 Aug 6. | | Abstract | Nuclear factor-kappaB (NF-kappaB) is a transcription factor that plays an essential role in cancer development. The results of our recent chemopreventive study demonstrate that kava, a beverage in the South Pacific Islands, suppresses NF-kappaB activation in lung adenoma tissues, potentially a mechanism responsible for kava's chemopreventive activity. Methysticin is identified as a potent NF-kappaB inhibitor in kava with minimum toxicity. Other kava constituents, including four kavalactones of similar structures to methysticin, demonstrate minimum activities in inhibiting NF-kappaB. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19716299 |
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