Pi X, Liu H, Wei K, Lin Y, Zheng X, Wen Z
A novel remote controlled capsule for site-specific drug delivery in human GI tract. [JOURNAL ARTICLE]
Int J Pharm 2009 Aug 27.
Remote controlled capsule (RCC) has been extensively used in the field of site-specific drug delivery. It is a potent tool to study the regional drug absorption of the gastrointestinal (GI) tract that provides pharmaceutical scientists with significant pharmacokinetics data for oral drug formulation development. In present investigations, a patented novel RCC has been devised based on micro-electronic mechanical system (MEMS) technology. Micro-thrusters were for the first time exploited as drug release actuators of RCCs. As the micro-thruster is ignited by a radio frequency (RF) signal, the thrust force generated by the propellants pushes the piston forward and leads to a rapid and complete expulsion of therapeutic agents from the capsule. The micro-thruster merely consumes 120 mW for ignition and the duration time of drug release is decreased to less than 1 second. The feasibility of the novel RCC was evaluated through animal experiments in beagles using aminophylline as the model drug. The novel RCC developed is a promising alternative for site-specific drug delivery in human GI tract.
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