| Title | Gene expression profiling related to anti-inflammatory properties of curcumin in K562 leukemia cells. | | Author(s) | Teiten MH, Eifes S, Reuter S, Duvoix A, Dicato M, Diederich M | | Institution | Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hôpital Kirchberg, Luxembourg, Luxembourg. marie_helene.teiten@lbmcc.lu | | Source | Ann N Y Acad Sci 2009 Aug.:391-8. | | MeSH | Anti-Inflammatory Agents, Non-Steroidal
Cell Cycle Proteins
Curcumin
Gene Expression Profiling
Gene Expression Regulation, Leukemic
Humans
K562 Cells
Leukemia, Erythroblastic, Acute
Oligonucleotide Array Sequence Analysis
Tumor Necrosis Factor-alpha
| | Abstract | A strong relationship exists between inflammation and carcinogenesis. To bring insights into the anti-inflammatory mechanisms by which chemopreventive agents, such as curcumin, are able to counteract the action of inflammation mediators, such as tumor necrosis factor-alpha (TNF-alpha), we compared gene expression profiles in K562 cells treated with curcumin-TNF-alpha versus TNF-alpha alone. Microarray data analysis revealed that, among the 376 differentially expressed genes by curcumin treatment, genes belonging to the cell cycle and the Janus kinase-signal transducer and activator of transcription signaling pathways were downregulated. This study also indicated that the upregulation of the heat shock family genes is highly implicated in the anti-inflammatory effect of curcumin. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
| | PubMed ID | 19723081 |
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