Distribution of tetracycline and erythromycin resistance genes among human oral and fecal metagenomic DNA. Microbial drug resistance (Larchmont, N.Y.) [Microb Drug Resist] Journal article | | Title | Distribution of tetracycline and erythromycin resistance genes among human oral and fecal metagenomic DNA. | | Author(s) | Seville LA, Patterson AJ, Scott KP, Mullany P, Quail MA, Parkhill J, Ready D, Wilson M, Spratt D, Roberts AP | | Institution | Division of Microbial Diseases, UCL Eastman Dental Institute, London, United Kingdom. | | Source | Microb Drug Resist 2009 Sep; 15(3):159-66. | | Abstract | We have analyzed the total metagenomic DNA from both human oral and fecal samples derived from healthy volunteers from six European countries to determine the molecular basis for tetracycline and erythromycin resistance. We have determined that tet(M) and tet(W) are the most prevalent tetracycline resistance genes assayed for in the oral and fecal metagenomes, respectively. Additionally, tet(Q), tet(O), and tet(O/32/O) have been shown to be common. We have also shown that erm(B), erm(V), and erm(E) are common erythromycin resistance genes present in these environments. Further, we have demonstrated the ubiquitous presence of the Tn916 integrase in the oral metagenomes and the Tn4451 and Tn1549 integrase genes within the fecal metagenomes. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
| | PubMed ID | 19728772 |
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